I N T E G R A T I V E C A N C E R T R E A T M E N T S
1. Jadvar, H., Xu, A., Tumeh, P., Pollock, J., & Nezami, M. (2005, November). Surveillance and Management of Lymphoma with Serial FDG PET-CT. Retrieved August 07, 2017, from http://archive.rsna.org/2005/4407297.html
2. Nezami, M.A., Stobbe, D., & Gould-Simon, A. (2015, August 1). Angiogenesis: cause or effect? Companion diagnostics and surrogate markers for a novel antiangiogenic therapy multitargeted epigenetic therapies (MTET). Retrieved August 07, 2017, from https://www.thefreelibrary.com/Angiogenesis: cause or effect?%2BCompanion%2Bdiagnostics%2Band%2Bsurrogate...-a0427757449
3. Nezami, M. A., Stobbe, D., Gould-Simon, A. (2015). Prognostic surrogate markers for survival, a case series for a novel antiangiogenic therapy (multitargeted epigenetic therapies/MTET). Pancreatic Cancer Symposium, POSTER A39.
4. Nezami, M. A., Stobbe, D., Gould-Simon, A., & Hager, S. (2015). Abstract C140: Heterogenous approach for heterogenous disease, heterogeneity in cancer genomics and epigenetic approach. Molecular Cancer Therapeutics, 14 (12 Supplement 2).
http://scientonline.org/open-access/heterogenous-approach-for-heterogenous-disease-heterogeneity-in-cancer-genomics-and-epigenetic-approach.pdf
5. Nezami, M. A., Gould-Simon, A., Stobbe, D., & Hager, S. (2015). 495PEpigenetic regulation of hypoxia and heterogeneity. Annals of Oncology, 26 (Suppl 9). http://annonc.oxfordjournals.org/content/26/suppl_9/ix151.3.ful
6. Nezami, M. A., Hager, S., & Garner, J. (2015). EMT and Anti-EMT Strategies in Cancer. Journal of Cancer Therapy, 1013-1019.
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=60708
7. Nezami, M. A., Hager, S., & Garner, J. (2015). Epigenetic therapies, immune therapies, and anti-angiogenic therapies: The triad of oncology. Angiogenesis: Cause or effect?. Journal of Precision Medicine, 43-48.
http://www.thejournalofprecisionmedicine.com/wp-content/uploads/2015/12/NEZAMI1.pdf
8. Nezami, M. A., Hager, S., & Lanman, R. (2015). Abstract B86: Impact of multi targeted epigenetic therapy (MTET): A series of 100 consecutive advanced solid tumor cancers. Molecular Cancer Therapeutics, 14(12 Supplement 2). http://mct.aacrjournals.org/content/14/12_Supplement_2/B86.short
9. Nezami, M. A., Stobbe, D., & Hager, S. (2015). Abstract A122: Case review for multi-targeted epigenetic therapy (MTET) and its rationale in an integrative approach. Cancer Research, 75 (13 Supplement).
10. Nezami M. A. (2015, November). Prognostic surrogate markers for survival, a case series for a novel antiangiogenic therapy (Multitargeted epigenetic therapy/MTET), 12th International Conference of the Society of Integrative Oncology (SIO).
https://integrativeonc.org/docman-library/events/conference-materials/182-sio2015-poster-abstracts/file
11. Nezami, M. A., Stobbe, D., Gould-Simon, A., and Hager, S. (2015, November). Abstract C140: Herogenous approah for heterogenous disease, heterogeneity in cancer genomics and epigenetic approach. Molecular Cancer Therapeutics.
http://mct.aacrjournals.org/content/14/12_Supplement_2/C140.short
12. Nezami, M. A., Simon, A. G., & Bartholomeusz, G. (2016). Correlation of an ex Vivo Model with Clinical Application of an Epigenetic Modifier, Inhibiting Tumor Growth and Metastasis, in Resistant Cholangiocarcinoma—A Case Study. Journal of Cancer Therapy, 07(01), 50-54. http://www.scirp.org/journal/PaperInformation.aspx?PaperID=63102
13. Nezami, M. A., Hager, S., & Garner, J. (2016). The Role of Telomeres in Cancer Development and Progression, and the Double Edge Sword Effect with Tamoxifen. Biology and Medicine, 8:3. https://www.omicsonline.org/open-access/the-role-of-telomeres-in-cancer-development-and-progression-and-the-double-edge-sword-effect-with-tamoxifen-0974-8369-1000296.php?aid=71587
14. Nezami, M. A., Hager, S., & Garner, J. (2016). Preliminary Findings on Multi-Targeted Epigenetic Therapy in Modifying Telomerase Activity. Cancer Science Open Access, 2:1:007.
http://scientonline.org/open-access/preliminary-findings-on-multi-targeted-epigenetic-therapy-in-modifying-telomerase-activity.pdf
15. Nezami, M. A., Hager, S., & Garner, J. (2016). Epigenetic Tumor Response to Hypoxia: An Epimutation Pattern and a Method of Multi Targeted Epigenetic Therapy (MTET). Journal of Cancer Therapy, 254-269.
http://www.scirp.org/journal/PaperInformation.aspx?PaperID=65475
16. Nezami, M. A., Hager, S. (2016, May). Abstract B22: Invitro and invivo proof of concept for an effective antineoplastic combination of novel anti HIF therapy in pancreatic cancer. Cancer Research.
http://www.aacr.org/Documents/Panc16_Poster_Session_B_Web.pdf
17. Nezami, M. A. (2016). Chemoprevention and epigenetic multitargeted approach. Journal of Clinical Oncology, 2016 Cancer Survivorship Symposium: Advancing Care and Research.
http://ascopubs.org/doi/abs/10.1200/jco.2016.34.3_suppl.e297
18. Nezami, M. A. (2016, November). Epigenetic therapies and the use of multitargeted approach, A new concept in cancer therapeutics. Journal of Cancer Science & Therapy, 14th World Cancer & Anti-Cancer Therapy Convention.
https://www.omicsonline.org/proceedings/epigenetic-therapies-and-the-use-of-a-multitargeted-approach-a-new-concept-in-cancer-therapeutics-62410.html
19. Nezami M. A. (2016, November). Biological interventions to interfere micro-environmental and endocrine machinery in cancer: Application of endocrine manipulation in advanced cancer. Journal of Cancer Science & Therapy, 14th World Cancer & Anti-Cancer Therapy Convention. https://www.omicsonline.org/proceedings/biological-interventions-to-interfere-microenvironmental-and-endocrine-machinery-in-cancer-application-of-endocrine-mani-62425.html
20. Nezami, M. A., Garner, J. (2017, June). Role of Anti Angiogenic Therapy in Prevention of Recurrence in Hormonal Positive Breast Cancer: A Secondary Prevention Strategy and Method of Therapy. Journal of Cancer Therapy, Vol.8 No.6, June 2017 https://www.scirp.org/Journal/PaperInformation.aspx?PaperID=76988
21. M.Nezami MD "Biological modulation of PARP inhibition in triple-negative breast cancer: A case report of combinational approach implementing specific histone deacetylase inhibitors with PARP inhibition in advanced breast cancer"
AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics, Philadelphia, PA Oct 26th, 2017, Volume 17, Issue1, http://mct.aacrjournals.org/content/17/1_Supplement/LB-A25
22..A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=83123
Julie Taguchi, Christopher Duma, M. Nezami MD,
Journal of Cancer therapy, March 2018
23. Landscape of BRCA1 and BRCA2 germline, somatic, and reversion alterations detectable by cell-free DNA testing among patients with metastatic breast, ovarian, pancreatic, or prostate cancer
Aditya Bardia1, Thereasa A. Rich2, Victoria M. Raymond2, Stephen R. Fairclough2, Oliver Sartor3, Michael B. Lilly4, Mohammad Amin Nezami5, Sandip Patel6, Benedito A. Carneiro7, Grace Wang8, Alice C. Fan9, Adam M. Brufsky10, Barbara A. Parker6, Benjamin B. Bridges11, Neeraj Agarwal12, Benjamin L. Maughan12, Richard B. Lanman2, Massimo Cristofanilli13.
ASCO 2018
24. M.Nezami MD, Christopher Duma MD "Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments", Journal of Cancer Therapy ( JCT), Volume 9, No. 6, June 2018, 10.4236/jct.2018.96043
25. M.Nezami , Steve Hager, Julie Taguchi, "Biological Modulation of PARP Inhibition in Triple Negative Breast Cancer, a Combinational Approach Implementing Multitargeted Epigenetic Therapy (MTET) with PARP Inhibition, in Advanced Breast Cancer: A Case Study".
JCT> Vol.9 No.9, September 2018, ISSN 2151-1942 DOI: 10.4236/jct.2018.99060
26. M.Nezami, Steve Hager " Evidence Based Medicine, in Precision Oncology, JCT, Vol9, Number 9, 679-805, Sept 2018,
Journal of Cancer Therapy, https://file.scirp.org/pdf/JCT_2018091015385090.pdf
27. M.Nezami MD, Stave Hager DO, Aron Gouldsimon MD, "Induction of cell differentiation and genomic stability in cancer, by an “multi epimutation-targeted therapy”, or MTET", Open Access Text ( OAT), September 2018, ISSN: 2516-5283 https://www.oatext.com/pdf/CMR-1-129.pdf
28. M.Nezami , A GouldSimon, Jessica Garner," Preliminary findings on a sequential and combined targeted epigenetic therapy through MAPK and MEK inhibition: A case study of advanced neuroendocrine malignancy, Open Access Text ( OAT), September 2018, ISSN: 2516-5283
29. M.Nezami MD, S Hager DO, Clinical implications of epidermal growth factor receptor (EGFR) epigenetic modification in lung cancer, proof of concept for dual multitargeted epigenetic therapy (MTET) in combination with EGFR inhibitors, January 2018, DOI: 10.15761/CMR.1000132https://www.researchgate.net/publication/328453409
30. Mohammad Nezami, Steve Hager, Journal of Cancer Therapy, 2018, 9, http://www.scirp.org/journal/jct
Dual Epidermal Growth Factor Inhibition and Multi Targeted Epigenetic Therapy (MTET)
31. M.Nezami MD," Sequential and Dual Inhibition of Pleiotropic Targets in Cancer—A Novel Strategy to Sensitize Tumor Cells to Targeted Therapies and Overcome Resistance" Journal of Cancer Therapy, 2019, 10, 166-17
32. M.Nezami MD, Jessica garner, " Preclinical and preliminary clinical reports for successful treatment of ovarian cancer with standard treatments in
combination with epigenetic modiers in a complimentary and integrative approach", Open access text, ISSN 2516-5283
33. M.Nezami MD " Questionable alternative therapies for cancer, “ The devil is in the detail”
Mini Review, Clinical and Medical Reports, Clin Med Rep, 2019 doi: 10.15761/CMR.1000142
Volume 2: 1-2, ISSN: 2516-5283
34. Mohammad A. Nezami, Christian Klowsowski, Steven Jeffrey Hager; Research Cancer Institutes of America, Sahel Oncology, Newport Beach, CA; Guardant health, Genomic Specialist, Medical Affairs, Redwood City, CA; California Cancer Associates for Research and Excellence, Fresno, CA
“ Predictive molecular tumor response through circulating DNA (cDNA) measurements and correlation with established prognostic markers in a series of solid tumors treated with multitargeted epigenetic therapy (MTET)"
J Clin Oncol 37, 2019, https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.e13015?af=R
ASCO 2019
35. Identification of actionable fusions as an anti-EGFR resistance mechanism using a circulating tumor DNA assay, ASCO 2019, Annals of Oncology JCO Precision Oncology, 2019, https://ascopubs.org/doi/pdf/10.1200/PO.19.00141
Katherine Clifton, MD1+, Thereasa A. Rich2+, Christine Parseghian, MD1, Victoria M. Raymond2, Arvind Dasari, MD1, Allan Andresson Lima Pereira, MD1, Jason Willis, MD1, Jonathan M. Loree, MD3, Todd Bauer, MD4 , Young Chae, MD5, Gary Sherrill, MD6, Paul Fanta, MD7, Axel Grothey, MD8, Andrew Hendifar, MD9, David Henry, MD10, Daruka Mahadevan, MD11, Mohammad Amin Nezami, MD12, Benjamin Tan, MD13, Zev Wainberg, MD14, Richard Lanman, MD2, Scott Kopetz, MD1, Van Morris, MD1*
1The University of Texas-MD Anderson Cancer Center, Houston TX, 2GuardantHealth Inc., Redwood City, CA, 3BC Cancer, Vancouver, CA, 4Tennessee Oncology, Nashville, TN, 5Northwestern University Feinberg School of Medicine, Chicago, IL, 6Cone Health Cancer Center, Greensboro, NC, 7University of San Diego Moores Cancer Center, La Jolla, CA, 8The University of Tennessee West Cancer Center, Memphis, TN, 9Cedars-Sinai Medical Center, Los Angeles, CA, 10University of Pennsylvania, Philadelphia, PA, 11The University of Arizona Cancer Center, Tucson, AZ, 12 Pacific Medical Center of Hope, Fresno, CA, 13Washington University School of Medicine, St. Louis, MO, 14University of California Los Angeles, Los Angeles, CA
36. M.Nezami ," Invitro and invivo correlation of biomarker response to epigenetic therapy in pancreatic cancer", Clinical and Medical reports, Open Access Text, ISSN: 2516-5283, July 2019, DOI: 10.15761/CMR.1000149
37. M.Nezami, Steve Hager, Christian Klowski, "Correlation of circulating DNA( cDNA) alterations in several genes with established prognostic markers in a series of solid tumors treated with Multi Targeted Epigenetic therapy(MTET)", open access text, DOI: 10.15761/CMR.1000150, July 2019
38. Neelima Vidula" nvidula@mgh.harvard.edu, "Oliver Sartor" osartor@tulane.edu,... "Mohammad Amin Nezami" "Sandip P. Patel" spatel@ucsd.edu, "Benedito A. Carneiro" benedito_carneiro@brown.edu, "Alice C. Fan" afan@stanford.edu, "Adam M. Brufsky" ambrufsky@upmc.edu, "Barbara A. Parker" baparker@ucsd.edu, "Benjamin B. Bridges" "Neeraj Agarwal" neeraj.agarwal@hci.utah.edu, "Benjamin L. Maughan" benjamin.maughan@hci.utah.edu, "Victoria M. Raymond" , "Stephen R. Fairclough" "Richard B. Lanman" "Aditya Bardia" bardia.aditya@mgh.harvard.edu
" Routine plasma-based genotyping to comprehensively detect germline, somatic, and reversion BRCA mutations among patients with advanced solid tumors", Journal of Clinical Oncology, Sept, 2019
39. M.A.Nezami, "Mutated allele fraction( MAF) of epigenetically driven target genes, A biomarker assay to support clinical management in solid tumors treated with multi targeted epigenetic therapy( MTET)", Advances in Cancer Research & Clinical Imaging, Sep 2019, (ISSN: 2688-8203), DOI: 10.33552/ACRCI.2019.02.000532
40. M.Nezami MD, Steve Hager DO, Christian Klowski,"Retrospective review of 374 sample, circulating DNA; to support clinical management in solid tumors treated with multi targeted epigenetic therapy( MTET)", Clinical Case Studies Reviews & Reports, Oct 2019, https://www.onlinescientificresearch.com/articles/retrospective-review-of-374-samples-circulating-dna-as-a-biomarker-assay-to-support-clinical-management-in-solid-tumors-treated-wi.pdf
41. Caroline M. Weipert, Thereasa A. Rich, Rebecca J. Nagy, Ben Park, Brian Leyland-Jones, Joyce O’Shaughnessy, Mohammad Nezami, Massimo Cristofanilli, Aditya Bardia, Richard B. Lanman,
" Cell-free DNA (cfDNA) analysis of ESR1-mutant advanced breast cancer (aBC): Impact of subsequent therapy on mutation persistence"
San Antonio Breast Cancer Symposium, 2019
42. Neelima Vidula, Thereasa Rich, Oliver Sartor, Jennifer Yen, Aaron Hardin, Tracy Nance, Michael Lilly, Mohammad Amin Nezami, Sandip Patel, Benedito Carneiro, Alice Fan, Adam Brufksy, Barbara Parker, Benjamin Bridges, Neeraj Agarwal, Benjamin Maughan, Victoria Raymond, Stephen Fairclough, Richard Lanman, Aditya Bardia, and Massimo Cristofanilli, Manuscript Number: CCR-19-2933
Routine plasma-based genotyping to comprehensively detect germline, somatic, and reversion BRCA mutations among patients with advanced solid tumors
Clinical Cancer Research, 2019
43. M.Nezami MD, "A Retrospective Review of 300 Case Reports, Quality of Life and Correlation With Biomarkers Related to Tumor Burden, in Advanced Cancer", Journal of Biology and Medicine, Open access, August 2020, https://www.longdom.org/open-access
44. M. Nezami MD, Vicky Yamamoto, PhD, " Biological disruptive therapies as counter measures for unpredictable biological insults, A case for successful treatment of Covid 19", journal of Infectious Diseases( AID), SCRIP, August 2020, DOI: 10.4236/aid.2020.103018
45. Amr Kamel Khalil Ahmed, Mohammad Nezami, Abdullah Alkattan, Ahmed Mohamed, Omar Alshazly, Simona Ibrahim, " After one year of COVID-19 Pandemic and Hundreds of Suggested Drugs, Will Cathepsin L Inhibitors be the Solution?", Open science, DOI:10.5281/zenodo.4682214, April, 2021
46. Amr Ahmed1 , Mohammad Nezami2 , Abdullah Alkattan3 "Pitfalls at Chemistry of Adenoviral Vector Vaccine against COVID-19 and how to Circumvent It", Advanced Pharmaceutical Bulletin, 2021, Iran, apb-32857, Open science, 1Department of Public Health, Tuberculosis Program, First Health Cluster, Ministry of Health, Riyadh, Saudi Arabia.
47. M.Nezami MD, " Addressing disparities in oncology care, Minorities, African American, Holocaust victims,
and prisoners(“ limited access groups”), defeating racism in oncology care
J Oncol Res Rev Rep 2021, Volume 2(5): 3-3, October 2021
48. SAMIA S. MESSEHA, MOHAMMAD A. NEZAMI, STEVEN. HAGER , AND KARAM
F.A. SOLIMAN" A Rare Presentation of a Non-Asian Female with Metastatic Non-small-cell Lung
Cancer Harboring EGFR L747P Mutation With Clinical Response to Multitargeted
Epigenetic and EGFR Inhibition", PubMed, Anticancer Res. 2022 Jan;42(1):441-447.
98. M. Nezami MD, " A case study of de-staging and reverse transformation of a IDH mutated malignant metastatic sarcoma to benign tumor and complete clinical remission by application of Multitargeted Epigenetic therapy", Progress in medical sciences, Vo 6, 6, page1-5, December 2022, DOI:10.47363/PMS/2022(6)183
49. Nezami M.A. " Prospects of a novel therapeutic targeting fibroblast growth factor receptor in a case series of patients with advanced solid tumors", Open scientific publishing, OSP journal of health care and medicine, Jan. 2023
50. M. Nezami MD, " Detection technologies and clinical correlation of epigenetic marks in Circulating tumor cell analysis in solid tumors", Future Genomics, Boston, Massachusetts, March 22, 2023, Future Genomics 2023 (future-genomics-conference.com)
51. Nezami M.A, " Fibroblast Growth Factor Receptor( FGFR) as a target for epigenetic therapies, a case review for a new approach to target tumors with somatic mutations/ amplifications of FGFR, European Society of Medical Oncology( ESMO) Targeted Anticancer Therapies Congress 2023, 6-8 March 2023, Paris, France, Abst 218, 24P
52. M. Nezami MD, " A case study of de-staging and reverse transformation of a IDH mutated malignant metastatic sarcoma to benign tumor and complete clinical remission by application of Multitargeted Epigenetic therapy", Progress in medical sciences, Vo 6, 6, page1-5, January 2023
53. M.Nezami MD, Transition from Crime to care in Oncology, https://www.amazon.com/Transition-Crime-Care-Mohammad-Nezami/dp/B0B6XFK4X8/ref=sr_1_1?crid=CSOD16599PZI&keywords=Transition+from+crime+to+care&qid=1658420248&s=books&sprefix=transition+from+crime+to+care%2Cstripbooks%2C49&sr=1-1
54. M.Nezami, S hager, R Shirazi, " Transforming Growth Factor and the Role of Epigenetic Aberrancies in Oncogenic Amplifications: A New Perspective in Preventive and Therapeutic Arena", Journal of Cancer Therapy, 2023, 14, 390-407 https://www.scirp.org/journal/jct ISSN Online: 2151-1942
55. M Amin Nezami, Steven Hager, A Chaychian " Application of epigenetic therapies in combination with cyclin dependent kinase inhibitors (CDKIs) in patients with metastatic breast cancer to reverse tumor resistance: two case reports", Journal of Biology and Medicine, Vol 8, issue 4, Oct 2023, MOJ Biol Med. 2023;8(4):153-157. DOI: 10.15406/mojbm.2023.08.00202
56. Nezami MD, Steven Hager DO, Aryan Chaychian, " Epigenetic Aberrancies as the Exclusive Driver of Oncogenic Amplifications", PROGRESS IN MEDICAL SCIENCES, 2023 VOL 7, NO. 5, PAGE 1 – 6 DOI: doi.org/10.47363/PMS/2023(7)192
57. 2024: Kabir Mody, Afsaneh Barzi, M. Nezami, Carin Espenschied, Victoria Raymond , Daruka Mahadevand," ERBB2 (HER2) amplifications and co-occurring KRAS alterations in the circulating cell-free DNA of pancreatic ductal adenocarcinoma patients and response to HER2 inhibition", Frontiers in Oncology, section Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers, Feb, 2024
58. Author, Book; Making the case for MTET, where miracles become standard in oncology, publish date March 2024
P U B L I C A T I O N S
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Mohammad Nezami ©